New investigation results, 'Rosai-Dorfman disease confined to the breast,' are detailed in a study published in Annals of Diagnostic Pathology. "Rosai-Dorfman disease (also known as sinus histiocytosis with massive lymphadenopathy) is an uncommon, idiopathic, benign histiocytic lesion. It usually involves the cervical lymph nodes and, less commonly, extranodal sites," scientists in the United States report (see also Non-Langerhans-Cell Histiocytosis).
"Involvement of the breast is rare, with only 17 cases reported in the English literature to date. Here we describe 3 new patients with extranodal Rosai-Dorfman disease in the breast. All 3 patients-aged 45, 53, and 54 years-presented with solid breast lesions that were detected on screening mammography and had no clinical history of Rosai-Dorfman disease or radiographic evidence of extramammary involvement. Initial diagnoses were accomplished by needle core biopsy in the one case and excisional biopsy in the other two. We present the histopathologic findings and follow-up of each patient and conduct a literature review of mammary Rosai-Dorfman disease with emphasis on its differential diagnosis," wrote J.J. Morkowski and colleagues, University of Texas M.D. Anderson Cancer Center, M.D. Anderson Cancer Center.
The researchers concluded: "Because Rosai-Dorfman disease frequently mimics invasive breast carcinoma in its clinical presentation and radiographic appearance-and can mimic other benign or malignant histiocytic lesions microscopically-awareness and appropriate diagnosis of this entity are essential for proper treatment."
Morkowski and colleagues published their study in Annals of Diagnostic Pathology (Rosai-Dorfman disease confined to the breast. Annals of Diagnostic Pathology, 2010;14(2):81-7).
For additional information, contact J.J. Morkowski, The University of Texas MD Anderson Cancer Center, Dept. of Pathology, Houston, TX 77030 USA.
Keywords: City:Houston, State:TX, Country:United States, Breast Cancer Screening, Breast Carcinoma Screening, Dermatology, Diagnostics, Hematology, Lymphadenopathy, Non-Langerhans-Cell Histiocytosis, Oncology, Pathology, Women's Health.
This article was prepared by Women's Health Weekly editors from staff and other reports. Copyright 2010, Women's Health Weekly via NewsRx.com.
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