"Impaired insulin secretion plays a key role in the development of cystic fibrosis-related diabetes (CFDR). Numerous indices to evaluate insulin secretion have been proposed, but their validity has not been explored in cystic fibrosis (CF)," scientists writing in the Journal of Cystic Fibrosis report (see also Cystic Fibrosis).
"The aim of the present study was to validate surrogate indices of insulin secretion in CIF patients against the gold standard, the intravenous glucose tolerance test (IVGTT). 32 subjects were enrolled: 16 controls, 10 cystic fibrosis-normal glucose tolerant (CF-NGT) and 6 CFRD patients. All subjects underwent a 2-h oral glucose tolerance test (OGTT) and an IVGTT. Insulin secretion was estimated using three indices: the HOMA-beta cell, the Stumvoll's early insulin secretion; and the insulin secretion rate (ISR). In control subjects, all insulin secretion indices correlated significantly with the IVGTT. In CF-NGT patients, the HOMA-beta cell correlated significantly with the IVGTT at shorter time points but not over longer time-period. On the other hand, both OGTT-derived indices (Stumvoll and IRS) correlated significantly with the lVGTT for die CF-NGT and CFRD groups. Since the OGTT is required on a regular basis in CF patients to screen for CFRD," wrote I. Hammana and colleagues.
The researchers concluded: "OGTT-derived indices appear to be suitable for evaluating insulin secretion."
Hammana and colleagues published their study in the Journal of Cystic Fibrosis (Validation of insulin secretion indices in cystic fibrosis patients. Journal of Cystic Fibrosis, 2009;8(6):378-381).
Additional information can be obtained by contacting I. Hammana, Inst Rech Clin Montreal, Platform Res Obes Metab & Diabet PRO MD, 110 Ave Pins Ouest, Montreal, PQ H2W 1R7, Canada.
The publisher of the Journal of Cystic Fibrosis can be contacted at: Elsevier Science BV, PO Box 211, 1000 AE Amsterdam, Netherlands.
Keywords: City:Montreal, Country:Canada, Cystic Fibrosis, Diabetes, Genetics, Hepatology, Pulmonology.
This article was prepared by Diabetes Week editors from staff and other reports. Copyright 2010, Diabetes Week via NewsRx.com.
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