PAMPLONA, Spain, Apr 27, 2009 (UPI via COMTEX) -- Spanish medical researchers
say they've identified a key enzyme that contributes to development of cardiac
insufficiency in some heart disease patients.
The scientists at the University of Navarra's Center for Applied Medical
Research said the enzyme is involved in the accumulation of fibrous tissues in
the hearts of patients with chronic cardiac diseases and deterioration of heart
functions.
In their study, the scientists analyzed the expression of Llysyl oxidase, an
enzyme that regulates the amount of fibrous tissue in cardiac muscle.
"By means of molecular and histological methods, we have found that the cardiac
muscle in patients with cardiac insufficiency contains an excess of this enzyme
as well as collagen fiber. These factors are associated with the deterioration
of cardiac functions," said Dr. Begona Lopez, who led the project.
The scientists said their findings show some drugs prescribed for patients with
cardiac insufficiency don't actually inhibit the enzyme lysyl oxidase, nor do
they reduce fibrosis or improve heart functions. Other drugs however, which are
less commonly used, do have these beneficial qualities.
"Our work opens new possibilities for treating patients with heart disease
through the inhibition of the enzyme," said Lopez.
The research appears in the journal Hypertension.
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Copyright 2009 by United Press International