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David Tabby was born in Philadelphia. He graduated from Princeton University in 1980 with a degree in Population Biology. Dr. Tabby earned his Osteopathic Medical degree from the Philadelphia College of Osteopathic Medicine in 1984. He completed his neurology residency at Thomas Jefferson under Robert J. Schwartzman, MD in 1988, where he served as chief resident. Dr. Tabby started in private practice in Philadelphia after residency and now returns to it after 12 years as an associate professor of neurology at the Drexel University College of Medicine. He was the Neurology clerkship director for fourth-year students, the director of the Neurology Residents’ clinic.

Dr. Tabby’s interest in multiple sclerosis (MS) started in his residency, when he worked with Fred Lublin, MD, and Robert Knobler, MD. He is certified by the Consortium of Multiple Sclerosis Centers. Dr. Tabby conducted numerous MS clinical trials and performed original research involving cognition and headache in MS.  He is a fellow of the American Academy of Neurology.

He provides initial diagnosis, second opinion, and ongoing care of patients with MS. His outpatient infusion center administers intravenous corticosteroids, immune globulin, and natalizumab (Tysabri®).  He also manages intrathecal baclofen pumps for spasticity.

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Intravenous Infusions (IVs):
-Natalizumab (Tysabri™) is an FDA approved medication for adult patients with relapsing forms of MS to slow the worsening of physical disability and to decrease the number of flare-ups (relapses). Tysabri™ is an antibody, unlike other MS treatments.  It is thought to inhibit white blood cells (T cells) from getting into the brain and attacking the myelin covering nerve fibers in the brain and spinal cord.  This is believed to result in fewer brain lesions that cause MS symptoms 
-Intravenous immune globulin (IVIG) are antibody proteins that are secreted by the white blood cells called B-lymphocytes and by plasma cells in response to the presence of a substance (antigen) that provokes an immune response. Intravenous immunoglobulin G (IVIG) is a pooled human immunoglobulin G (IgG) that is presumed to modulate the immune system. 
-Methylprednisolone is a synthetic corticosteroid.  Steroids are hormones normally produced in the human body by the adrenal glands. They have a number of physiologic effects on different organ systems, but are most widely used for their anti-inflammatory actions. Steroids were among the first agents used to treat MS and remain the treatment of choice for managing acute exacerbations, 
-Chronic Migraine
-Anti-nauseants (metoclopramide and ondansetron) can also directly treat headache pain.
-Magnesium Sulfate infusions are often helpful for migraine associated with neck pain and stiffness. 
-Dihydroergotamine (DHE) is the gold standard for treating chronic migraine.  DHE has a 10- to 14-hour half-life.  You will need an EKG first because of the risk of vasospasm.
-Valproate Sodium (Depacon™) was the first anticonvulsant molecule to be found useful in treating Migraines in a prophylaxis manner. 
-Levetiracetam (Keppra™) has a unique mechanism of action that blocks high-voltage calcium channels, another major activity of many neuronal stabilizing agents. Studies have supported its use in management of chronic migraine .
-Lacosamide (Vimpat™) is a seizure medication that has been shown to be effective for chronic migraine also.
-Ketoralac (Toradol™) is a potent IM or IV anti-inflammatory medication that is helpful for relieving pain and inflammation.
-Methylprednisolone is an IV corticosteroid useful in reducing the inflammation associated with chronic migraine.
-Botox injection
-Chronic migraine-BOTOX® is approved by the FDA to prevent headaches in adults with Chronic  Migraine who have 15 or more days each month with headache lasting 4 or more hours each day in people 18 years or older. Multiple injections are placed at sites around the head and upper neck.  Relief might last three to four months
-Spasticity is a state of increased tone of a muscle.  For example, with spasticity of the arms there is an increase in tone of the leg muscles so they feel tight and rigid. BOTOX® is approved by the FDA to treat increased muscle stiffness in elbow, wrist, and finger muscles in people 18 years and older with upper limb spasticity.

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