DALLAS, Mar 12, 2009 (UPI via COMTEX) -- A U.S. study of primates suggests
estrogen might become a new postnatal therapy to improve lung function and other
outcomes in preterm infants.
University of Texas Southwestern Medical Center Professor Philip Shaul, the
study's senior author, said the research was conducted at the Southwest
Foundation for Biomedical Research Primate Center in San Antonio.
"Ironically, a hormone that has received great attention as a potential means to
optimize the health of older women may be a beneficial treatment for humans
during the earliest stages of life," said Shaul. The research was part of an
investigation into the causes and treatments for bronchopulmonary dysplasia, a
primary complication of premature birth that develops in the preterm lung
following ventilation and oxygen support.
Shaul and his colleagues found administering estrogen to premature primates
accomplished several things, including creating a greater abundance of nitric
oxide synthases in their lungs, resulting in markedly enhanced lung function,
and a significantly reduced need for ventilation support.
That, said Shaul, represents an important step in lessening the lung injury that
causes BPD in humans and also prevent slow blood pressure, which is a common
problem in preterm infants.
The study is detailed in the American Journal of Respiratory and Critical Care
Medicine.
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